CDH2 and non-small cell lung carcinoma: It is worth noting that TGF-β can upregulate the expression of SIRT1, and SIRT1 overexpression can downregulate E-cadherin and upregulate N-cadherin, promoting the EMT of A549 cells (a NSCLC cell line), suggesting that SIRT1 may be an important protein in the TGF-β signaling pathway [13].