The protein concentrations of Th17 cytokines (IL-17, IL-23) were significantly higher in the 6-12y CRSwNP group compared to the13-18y CRSwNP and CRSsNP groups and the 6-12y or 13-18y control group (P < 0.05) (Table 5). The gene discussed is IL17A; the disease is chronic rhinosinusitis without nasal polyps.