Numerous studies show that S1PR1 expression or activation is tightly correlated with the inflammatory response to infectious diseases such as Newcastle disease virus infection [24], influenza A virus H1N1 [25], H9N2 infection [26], herpes simplex virus type 1 infection [27], Pseudomonas aeruginosa lung infection [28], and human immunodeficiency viruses HIV-1 infection [29]. This evidence concerns the gene S1PR1 and infectious disease.