LEP and obesity due to melanocortin 4 receptor deficiency: In addition, the administration of leptin did not activate the leptin‐signaling molecules phosphorylated signal transducer and activator of transcription 3 (pSTAT3), pSTAT5, and phosphorylated ribosomal protein S6 in AVPV kisspeptin neurons in these animals, indicating that diet‐induced obesity may induce leptin resistance affecting central reproductive functions.90