In addition, the administration of leptin did not activate the leptin‐signaling molecules phosphorylated signal transducer and activator of transcription 3 (pSTAT3), pSTAT5, and phosphorylated ribosomal protein S6 in AVPV kisspeptin neurons in these animals, indicating that diet‐induced obesity may induce leptin resistance affecting central reproductive functions.90 This evidence concerns the gene LEP and obesity disorder.