Recently, we demonstrated that the ALDH1A3 isoform was highly and uniquely expressed in mesenchymal glioma stem cells (MES GSCs) and that RNA interference-mediated suppression of ALDH1A3 expression affected the growth of MES GSCs, suggesting ALDH1A3 as a potential target for glioblastoma treatment3. The gene discussed is ALDH1A3; the disease is central nervous system cancer.