The mechanism of hypoalbuminemia during sepsis may be that: (1) sepsis causes capillary leakage, thus albumin enters the interstitial fluid12; (2) sepsis causes a state of high catabolism in patients, and albumin is decomposed13; and (3) albumin is synthesized in the liver, and sepsis-caused inflammatory factors lead to the decline of liver synthesis function14. This evidence concerns the gene ALB and Hypoalbuminemia.