Additionally, CD44 was upregulated in ccRCC tissues (n = 533) compared with normal renal tissues (n = 72) in TCGA samples (Fig. 6E and Supplementary File 3), and its expression levels were positively associated with the clinical stage, pathological stage, T stage, N stage, and M stage of ccRCC patients (Fig. 6F–J). The gene discussed is CD44; the disease is nonpapillary renal cell carcinoma.