To further verify the Meg3-miR-708 interaction, a luciferase reporter assay was performed by co-transfecting CRC cell lines either with pGL3-Meg3-WT in combination with the miR-708 agomir or with pGL3-Meg3-Mut in combination with the miR-708 antagomir. This evidence concerns the gene MEG3 and colorectal carcinoma.