To further confirm the function of the Meg3/miR-708/SOCS3 axis in CRC development, we altered the expression of Meg3 and SOCS3, either alone or together, in the colons of ApcminmiR-708−/− mice or Apcmin mice using adenovirus-mediated infection in vivo. This evidence concerns the gene SOCS3 and colorectal carcinoma.