To investigate whether these loci also have the ability to generate H3K4me3-BDs over proto-oncogenes involved in translocation events, we studied the KOPT-K1 T-ALL cell line that results in the juxtaposition of LMO2 and the super-enhancer of the TRA/TRD locus as a result of the translocation, t(11;14)(q13;q11). Here, LMO2 is linked to acute lymphoblastic leukemia.