T cell receptor loci (TRA, TRD, TRB, TRG) are also regulated by super-enhancers, undergo similar inherent somatic rearrangement events, and are involved in translocation events in T cell acute lymphoblastic leukemia (T-ALL) (Supplemental Fig. S9; Larmonie et al. 2013). Here, THRB is linked to T-cell acute lymphoblastic leukemia.