To provide mechanistic data to support the generation of H3K4me3-BD by super-enhancer relocation, we used our previously CRISPR-Cas9 engineered T-ALL cell line PEER, which contains the same 12-bp insertion upstream of the TAL1 gene, resulting in TAL1 overexpression (Navarro et al. 2015). This evidence concerns the gene TAL1 and acute lymphoblastic leukemia.