Most of the CpG sites within FGF1 (24/35), FGF2 (15/19), FGF3 (27/36), FGF5 (11/19), FGF7 (6/7), FGF10 (12/15), FGF11 (12/16), FGF12 (45/52), FGF13 (47/52), FGF14 (48/58), FGF18 (23/41), FGF19 (20/32), FGF20 (17/22), and FGF21 (8/8) exhibited a statistically significant correlation to mRNA expression of the corresponding gene in tumor tissue with promoter methylation proving to be inversely correlated to mRNA expression. This evidence concerns the gene FGF1 and neoplasm.