Most of the CpG sites within FGF1 (24/35), FGF2 (15/19), FGF3 (27/36), FGF5 (11/19), FGF7 (6/7), FGF10 (12/15), FGF11 (12/16), FGF12 (45/52), FGF13 (47/52), FGF14 (48/58), FGF18 (23/41), FGF19 (20/32), FGF20 (17/22), and FGF21 (8/8) exhibited a statistically significant correlation to mRNA expression of the corresponding gene in tumor tissue with promoter methylation proving to be inversely correlated to mRNA expression. The gene discussed is FGF5; the disease is neoplasm.