According to TCGA data analysis in N = 279 HNSCC tumors with previously identified HPV-status, aberrations (amplifications and mutations) of FGFR1 (10%), FGFR2 (2%), FGFR3 (2%), and CCND1 (31%) was frequently found in HPV(−) tumors. The gene discussed is FGFR2; the disease is head and neck squamous cell carcinoma.