Infection of IFN-α-treated IFITM1/2/3 knockout HFF by KSHV or RRV did not reach levels of untreated sgNT-transduced cells, unlike what was observed with A549 cells, suggesting that IFITM-mediated restriction of KSHV and RRV infection plays a comparatively minor role in the overall IFN-α-mediated restriction of these two herpesviruses in HFF. The gene discussed is IFITM1; the disease is infection.