In contrast, repression of the transcription of GSDMD and NLRP3 indeed decreased host cell survival (GSDMD P value = 0.0038; NLRP3 P value = 0.0185), and GSDMD gene knockdown increased intracellular pathogen growth in S. flexneri ΔvirG infection (Fig. 4A and B). The gene discussed is GSDMD; the disease is infection.