The advantage of using genome-wide screens to comprehensively identify host targets was indicated by the identification of many positive genetic hits with unknown functions in bacterial infection, such as PHF6 (PHD finger protein 6), PHIP (pleckstrin homology domain-interacting protein), and TRERF1 (transcriptional regulating factor 1) (Fig. 3D and Tables S3 and S4 at https://doi.org/10.17632/xn3vv2cdnk.1). Here, TRERF1 is linked to bacterial infectious disease.