The genes that we investigated were associated with the TLR1/2 signaling pathway (IRAK1, MYD88, and TRAF6), pyruvate catabolism (PDHB, DLAT, and CS), the type I interferon pathway (TYK2), the TNF receptor signaling pathway (TNFRSF1A), a cytosolic immune receptor (ALPK1), p53 regulation (TP73), and inflammasomes (GSDMD and NLRP3), as well as unknown functions in bacterial infection (PHF6, PHIP, and TRERF1). The gene discussed is TRERF1; the disease is bacterial infectious disease.