In adolescence, skeletal growth and bone mass gain are influenced by estrogens and androgens, with an important interaction between androgens, growth hormone (GH) and insulin-like growth factor (IGF-1).14, 15Androgenic deficiencies can result in delayed puberty, manifested mainly by the absence of development of secondary sexual characteristics and primary amenorrhea, with hormone replacement being the first choice of treatment. The gene discussed is GH1; the disease is Primary amenorrhea.