TP53 and adrenal cortex carcinoma: Another marker that can be used for this identification is Ki-67, most expressed in areas with HGT.12In addition to these, some studies have shown that p53 genes have increased expression in the high-grade component, although other studies show that this marker may also have increased expression in well-differentiated ACC.8, 10, 11, 12There is evidence that overexpression of the p53 gene in well-differentiated ACC is accompanied by a worse prognosis.