PTEN and posterior cortical atrophy: We showed that FCGR3A gene amplifications and mRNA upregulation accounted for 9% of the metastatic PCa cases, in which 61% cases had AR gene amplifications and mRNA upregulation, 19% had PIP5K1A gene amplification and mRNA upregulation, and 37% cases had PTEN gene mutation, deletion, or mRNA downregulation.