M3G8 blocks both FcγRIIIa and FcγRIIIb, we found that M3G8 treatment led to an inhibition of FcγRIIIa and reduced expression of PIP5K1α/AKT, as determined by our immunoblot analysis by using antibody against FcγRIIIa, Further, the inhibitory effect of M3G8 treatment on PCa tumor growth is comparable to the effect of FcγRIIIa knockdown on PCa tumor growth. The gene discussed is FCGR3A; the disease is neoplasm.