Immunohistochemical analysis of tumor tissues further revealed that M3G8‐treated tumors exhibited reduced expression of PIP5K1α and VEGFR2 as compared to that of controls (for PIP5K1α, P = 0.01; for pAKT, P = 0.02; and for VEGFR2, P = 0.01; Fig. 6D,E). The gene discussed is KDR; the disease is neoplasm.