ACE2 and kidney disorder: Given the importance of ACE2 enzymatic processing of Ang II to Ang-(1–7) in protection against pathogenic features of multiple cardiovascular and kidney diseases [41,45,46], it is possible that that the extant mutational combinations observed in nature (e.g., human, bat, dog, mouse, and pangolin) may all represent alternative sequence “solutions” [29,77] each uniquely required for an animal’s physiology, thereby representing fitness “peaks” in the sequence landscape [29,31,34,78–81].