While the direct effect of HSPA8/HSC70 on the development of schizophrenia needs to be established, there is some potential impact on the SCZ pathogenesis through the various critical functions that are performed by the HSC70 in the CNS (HSC70 is involved in the turnover of the synaptic proteins, clathrin-mediated endocytosis, neurotransmitter homeostasis, and also participates in many neuroprotective mechanisms). Here, HSPA8 is linked to schizophrenia.