MIIP and nonpapillary renal cell carcinoma: To explore the underlying mechanism through which MIIP exerts its inhibitory effect on ccRCC cells, we performed RNA sequencing (RNA-Seq) in 786-O-MIIP vs. 786-O-Vector cells, given that the 786-O cell line has been widely used as a model of representative VHL-mutant ccRCC cells26,27.