MIIP and nonpapillary renal cell carcinoma: To determine the role of MIIP in ccRCC cells, we first established MIIP-stably overexpressing OS-RC-2 and 786-O and MIIP-silenced HK-2 and 786-O cell lines through lentivirus infection, on the basis of the endogenous expression of MIIP in HK-2 cells and several ccRCC cell lines (Supplementary Figure S1A).