In order to confirm this hypothesis, we therefore compared innate immunity induction by all these respiratory viruses (of this study) at 2 dpi in the context of single infections, and showed 0.5-1.4 log10 (Figures 3C), 2–3 log10 (Figures 3D), and 0.9–1.3 log10 (Figure 3E) lower induction of IFN-β, IFN-λ and IFN-stimulated gene 15 (ISG15), respectively by SARS-CoV-2 compared to common seasonal respiratory viruses. This evidence concerns the gene ISG15 and infection.