In response to RV and influenza infections, IFN-β and -λ were induced (log10 fold changes in the range of 0.12–1 for IFN-β and 1.85–2.86 log10 fold change for IFN-λ) and showed, compared to IBV, higher upregulation in RV and IAV pre-infected tissues. This evidence concerns the gene IFNB1 and influenza.