GPT and blood coagulation disease: A decision to euthanize all animals in this study was made based on clinical pathology findings suggestive of coagulopathy, including platelet decreases (down to a 0.06-fold baseline value, corresponding to 24,000 platelets/μL) and massive increases in ALT (up to a 40.7-fold baseline value, corresponding to 2,608 U/L).