TLR4 and Peri-Implantitis: Previous studies have shown that the anti-inflammatory microRNA miR-146a enhances the inhibition of peri-implant bone resorption through the regulation of TLR2/4 signaling [39] and Wnt5a involved in TLR4 signaling induces the production of inflammatory cytokines and causes breakdown of extracellular matrix in peri-implantitis [40].