To further illustrate the molecular mechanism of miR-301a-3p in SLE, the miR-301a-3p inhibitors and si-PELI1 vectors were cotransfected into the S-PMSCs, and the expression of IRAK1 and activity of NF-κB pathway were observed by western blot. The gene discussed is NFKB1; the disease is systemic lupus erythematosus.