TNF and Alzheimer disease: These interactions were ascribed to Gene Ontology biological processes, including necroptic process, activation of cysteine-type endopeptidase activity involved in apoptotic signal pathway, positive regulation of catalytic activity, proteolysis, and I-kappaB kinase/NF-kappaB signaling, and to Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways including apoptosis, AD pathways, and TNF signaling pathways.