Notable alterations in both cases included single copy losses affecting SMARCB1 (Fig. 1g), that were associated with low expression of SMARCB1 compared to both The Cancer Genome Atlas (TCGA) sarcoma18 data set and a pan-cancer cohort of adult cancers, referred to as POG570, sequenced as part of the POG programme19 (Fig. 1h and Supplementary Table 1). This evidence concerns the gene SMARCB1 and cancer.