To assess whether NLRP3 was also highly expressed in PCa tissues, a pairs of tumor tissues and matched adjacent non-cancerous tissues of PCa were selected for Immunohistochemical Staining, the results suggested that the expression level of NLRP3 in PCa tissue was significantly upregulated, compared to the paracancerous tissue (Fig. 1E). This evidence concerns the gene NLRP3 and neoplasm.