ELISA assay showed that the expression of IL-1β and IL-18 in the supernatant and lysate of PCa cells significantly increased in PC3 and LNCaP cells with sh-NLRP3 + recombinant protein caspase-1 by stimulation of LPS + ATP, compared with sh-NLRP3 alone (Fig. 4C). The gene discussed is CASP1; the disease is posterior cortical atrophy.