Subsequently, the recombinant protein caspase-1 and caspase-1 inhibitor, Z-YVAD-FMK was demonstrated to be able to counteract the proliferation, migration, and apoptosis effects of sh-NLRP3 and ov-NLRP3 in PCa cells by CCK-8, Tranwell assay, and TUNEL assay (Fig. 4E–G). Here, CASP1 is linked to posterior cortical atrophy.