ELISA assay showed that the expression of IL-1β and IL-18 in the supernatant and lysate of PCa cell lines significantly increased/decreased in PC3 and LNCaP cells with overexpression/knockout of NLRP3 by stimulation of LPS + ATP, compared with ov-NC/sh-NC (Fig. 3C, D). The gene discussed is IL18; the disease is posterior cortical atrophy.