In these models colitis had been induced by either bacterial infection with C. rodentium, 4 days of DSS supply with drinking water (short-term model) or 5 days of DSS supply plus 2 days without DSS (long-term model)41.We found that mRNA expression of iRhom2 but not iRhom1 is increased threefold in the long-term DSS model (Fig. 1A,B). Here, RHBDF2 is linked to colitis.