Genetic analyses in IHH families show that self-limited delayed puberty and IHH may share some overlap of their pathophysiology, with cases described of homozygous mutations in genes such as GNRHR26,27 and TAC3 and its receptor27 causing IHH, whilst heterozygous carriage of the same variants is associated with the phenotype of self-limited delayed puberty16,26,27. This evidence concerns the gene TAC3 and puberty.