ARL8B and cancer: The rs9311399 variant is located in the intron region of the ITPR1 gene, which is surrounded by several other genes, including SETMAR, EGOT, BHLHE40, BHLHE40-AS1, and ARL8B. In a previous study, EGOT was confirmed to be associated with a favorable prognosis and to enhance paclitaxel sensitivity in cancer patients35, suggesting a link between genetic variants at 3p26.1 and cancer survival.