The level of BNIP3L is high in organoids derived from murine pancreatic intraepithelial neoplasia, thereby delaying progression of pancreatic ductal adenocarcinoma (PDAC) and suggests BNIP3L-mediated mitophagy promotes tumorigenesis [118]. The gene discussed is BNIP3L; the disease is pancreatic ductal adenocarcinoma.