ADRA2A and schizophrenia: Due to the relevance of epigenetic changes in schizophrenia and given the possibility that histone PTMs at promoter regions could regulate ADRA2A and ADRA2C mRNA expression, we also evaluated PTMs of histone H3 (H3K4me3, H3K27me3, H3ac, H3K9ac, H3K27ac) and H4 (H4K5ac and H4K16ac) at promoter regions of both ADRA2A and ADRA2C genes.