Some of these findings are: altered expression of various enzymes, such as increased expression of histone methyltransferases (HMT) [18–20], histone deacetylase 1 (HDAC1) [21, 22], and reduced expression of HDAC2 [23, 24] in prefrontal cortex (PFC) of schizophrenia subjects. Here, HDAC1 is linked to schizophrenia.