To evaluate the possible epigenetic modulation of altered ADRA2A and ADRA2C mRNA expression in schizophrenia subjects, histone modification signature comprised of histone methylations—permissive H3K4me3 and repressive H3K27me3—and histone acetylations—H3ac, H3K9ac, H3K27ac, H4K5ac, and H4K16ac—was evaluated at both ADRA2A and ADRA2C promoter regions. The gene discussed is ADRA2A; the disease is schizophrenia.