ADRA2C and schizophrenia: The study of histone PTMs at ADRA2C promoter region in schizophrenia subjects showed a significant increase of H3K27me3 (Δ = +52%, p = 0.046, Fig. 4B), H3K9ac (Δ = +63%, p = 0.007, Fig. 4D) and H4K5ac (Δ = +55%, p = 0.027, Fig. 4F).