ADRA2A and schizophrenia: For ADRA2A promoter region, in schizophrenia subjects, both permissive H3K4me3 (Δ=+105%, p = 0.021, Fig. 3A) and repressive H3K27me3 (Δ = +86%, p = 0.01, Fig. 3B) were increased compared to matched controls.