As EMT (epithelial-mesenchymal transition) was considered as a cellular program which has been implicated in carcinogenesis and enhanced metastatic properties of cancer cells [25, 26], correlation analysis of LRG1 and two typical EMT markers including epithelial marker E-cadherin and mesenchymal marker N-cadherin was firstly performed using CPTAC database. This evidence concerns the gene CDH2 and cancer.