Several groups reported an inhibitory role of LRG1 on the migrative and invasive potential of different tumors including hepatocellular carcinoma (HCC) and esophageal squamous cell carcinoma (ESCC) [20, 21], whereas the underlying mechanisms have not been fully explored yet Our work demonstrated that LRG1 was highly expressed in metastatic CRC tissues. The gene discussed is LRG1; the disease is hepatocellular carcinoma.