In addition, as tumor progressed, percentage of patients with high LRG1 expression obviously increased, especially in patients with stage IV CRC (Fig. 6b) and this was further confirmed by bioinformatic analysis of data from CPTAC showing the protein level of LRG1 was highest in the tumors with the most advanced stage (Fig. 6c). Here, LRG1 is linked to colorectal carcinoma.