CD274 and hepatocellular carcinoma: However, the co-existence of intra- and inter-tumoral heterogeneity, with the latter one being much more profound and multifocal tumors being common in HCC, challenges precision immunotherapy since single tumor biopsy evaluation of PD-L1 expression or profiling genomic information could not represent the landscape of the whole tumor, let alone for multifocal HCCs.