Aside from the detection of mutations in genes involved in both T-ALL (i.e., ETV6, NOTCH1, DNM2) and myeloid malignancies (i.e., NRAS, JAK1, FLT3), recurrent mutations in two genes, DNMT3A and FAT3, were reported. The gene discussed is DNMT3A; the disease is acute lymphoblastic leukemia.