Moreover, low expression of the transcription factor GATA3 in a cohort of adult ETP-ALL cases was correlated with enrichment of myeloid/lymphoid progenitor and granulocyte/monocyte progenitor genes, while T cell-specific signatures were downregulated, suggesting a GATA3 role in the selection of a more immature leukemia-initiating cell [41]. This evidence concerns the gene GATA3 and acute lymphoblastic leukemia.