The results of UALCAN database analysis showed that the mRNA expression levels of CALR, CREB3L3, FBOX6, and KDELR3 were increased in cancer tissues compared with normal tissues, while the mRNA expression levels of CRYAB, DNAJB4, and HSPB6 were decreased in BLCA. The gene discussed is KDELR3; the disease is bladder transitional cell carcinoma.