And in the study of DZNep’s role on mice airway smooth muscle cells and human basal-like breast cancer cells, the NF-κB nuclear translocation was promoted via the IκB phosphorylation, which credited to the upregulated transcription of Foxc1 after the inhibition of EZH2 and subsequent H3K27me3 [12, 13]. The gene discussed is EZH2; the disease is breast cancer.