ACE and hypertensive disorder: To identify potential deleterious nsSNPs associated with ACE1 gene of high blood pressure, we used six different bioinformatics tools implemented in the following web servers: the Sorting Intolerant from Tolerant (SIFT) [9], Protein Variation Effect Analyzer (PROVEAN) [10], Polymorphism Phenotyping (PolyPhen-2) [11], SNPs&GO [12], Predictor of human Deleterious Single Nucleotide Polymorphism (PhD-SNPs) [13], PANTHER [14].