TXN and obesity due to melanocortin 4 receptor deficiency: Regarding the oxidative stress that is often increased in obesity and associated metabolic diseases, the thioredoxin (TXN) gene, which encodes the TXR protein a ubiquitously expressed small protein playing a key role in regulating the cellular redox status, was highlighted as a predicted regulator with a tendency towards activation in the HFIns treatment [125].