Wennberg and coworkers analyzed a cohort of 751 pathologically confirmed AD cases for TDP-43 status, APOE genotype, tau neurofibrillary tangle stage, and Aβ status and found a direct association between APOE4 and TDP-43; the association was mediated by Aβ and tau [145]. The gene discussed is TARDBP; the disease is Alzheimer disease.