Cryptic exon splicing has also been noted in AD with TDP-43 pathology, including those with cytoplasmic inclusion bodies and those with only nuclear depletion of TDP-43, suggesting that impairments of TDP-43 cryptic exon repression may be an early event in TDP-43 pathogenesis in FTLD, ALS and a subset of patients with AD [114]. The gene discussed is TARDBP; the disease is Alzheimer disease.