Moreover, loss, inactivation, or attenuation of PTEN is the most common genomic aberration of the PI3K and interactive pathways in various types of malignancies, with PTEN loss of heterozygosity (LOH) reported in hepatocellular (57% of patients), colorectal (48%), gastric (36%), prostate (52%), and endometrial (49%) cancers [79]. Here, PTEN is linked to cancer.