NOX4 and fibrosarcoma: In a carcinogen 3-methylcholanthrene (MCA)-induced fibrosarcoma mice model, NOX4 was proved to regulate the tumour-vessel density through stabilization of HIF-1α and induction of VEGF expression, while a significant 38% reduction in tumour vascularization in fibrosarcomas of Nox4-/- mice [75].