Tang et al. used papillomatosis thyroid cancer cells to study the cell growth by knocking down the expression of NOX4 and knocking out its functional partner p22phox/CYBA, the results suggested that NOX4 participated in regulating glycolysis through mROS-HIF1α pathway, thereby mediating proliferation in thyroid carcinomas [26]. The gene discussed is NOX4; the disease is thyroid cancer.