APOA1 and early-onset autosomal dominant Alzheimer disease: Interestingly, the Alzheimer disease (AD) subjects carrying ApoE ɛ4 allele had lower ApoA1 levels but higher ApoB levels [44] and there were differences in biomarker levels (e.g., cholesterol, LDL, and ApoB) for each ApoE genotype with reference to ε3ε3 in a UK Biobank study [45].