The purpose of this study is to explore the potential of CXCL12 and IL-1Ra to promote the metastasis of colon cancer and its mechanism, to better understand the interaction between colon cancer cells and stromal cells in tumor microenvironment, and to provide new ideas for the treatment of colorectal cancer and inhibition of liver metastasis of colon cancer. This evidence concerns the gene CXCL12 and colonic neoplasm.