In a second study, Tet2/3 fl/flFoxp3Cre mice lacking Tet2 and Tet3 in Treg cells were shown to develop inflammatory disease, with Treg cells from these mice exhibiting altered Treg gene signatures, with an associated upregulation in the transcription of genes involved in cell cycle, DNA damage and cancer. The gene discussed is TET2; the disease is cancer.