CD4 and neoplasm: Huang [21] demonstrate that targeting tumor vessel with low anti-VEGFR2 mAb induced in vascular normalization, which was manifested in more uniform distribution of functional vessels, and reversed immunosuppressed TME, as evidenced by promoting the polarization of TAM from M2 phenotype towards M1 phenotype and increasing the tumor accumulation of CD4+and CD8+ T cells.