NLRP3 and periodontitis: The animal results indicated that, after two weeks of treatment, Lipo-RSV effectively ameliorated periodontitis, evidenced by a decrease in the expression of inflammatory cytokines in the gingival tissue (Fig. 5B, C) and down-regulation of the essential proteins of NF-κB signaling (Fig. 5C) and inhibition of NLRP3 inflammatory signaling (Fig. 5D).