CALR and neoplasm: PTT allows for easier recognition of T cells by enhancing antigen exposure of tumor cells via a systemic anti-tumor immune response including the translocation of calreticulin (CRT) from the endoplasmic reticulum to the cell surface, the release of high mobility group B1 from the nucleus, the extracellular secretion of adenosine triphosphate and the expression of heat shock proteins (HSP) on the cell surface [24–26].