In particular, with the addition of IR780, the expression of HIF-1α in tumor tissues treated with 3BP@PLGA-IR780 was drastically less than that in cells treated with 3BP@PLGA, indicating that the tumor-targeted properties of IR780 endowed 3BP@PLGA-IR780 with more effective accumulation in tumor sites. The gene discussed is HIF1A; the disease is neoplasm.