Further, we also observed that acidic treatment increased the expression of YB-1 and Snail in a pH dependent manner, combined with an EndMT-like transformation of HUVECs, leading to an increase of endothelial permeability and facilitation of transendothelial migration of pancreatic cancer cells (BxPC-3, PANC-1). Here, YBX1 is linked to familial pancreatic carcinoma.