Five non-fatal serious AEs were reported; four in cipargamin patients (Grade 2 bilirubin increase from day 15 to day 21 (50 mg QD for 3 days), Grade 2 ALP increase from day 2 (75 mg single dose), Grade 3 ALT increase from day 4 to day 11 (150 mg single dose), Grade 4 thrombocytopaenia from day 9 to day 35 (75 mg single dose) and one in an artemether–lumefantrine patient (Grade 2 bilirubin increase from day 2 to day 8). The gene discussed is GPT; the disease is Thrombocytopenia.