SF3B1 and myelodysplastic syndrome: With the next-generation sequencing (NGS) analysis, more mutations are found to be involved in either primary or secondary MDS disease, such as epigenetic regulators (TET2, ASXL1, DNMT3A, IDH1, IDH2, EZH2), transcription factors (ETV6, RUNX1, TP53), signal transduction proteins (CBL, JAK2, KRAS, NRAS), and genes related to the RNA splicing machinery (SF3B1, SRSF2, U2AF1, ZRSR2) [9].